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Unwanted Immunogenicity: From Risk Assessment to Risk Management
via bioprocessintl

Although vaccines and immunotherapies are designed to engage the human immune system in fighting disease, unwanted immunogenicity can be a major problem for protein-based therapeutics. Some patients produce antidrug antibodies (ADAs), which might lead...
Validation of a Novel Tumoroid-Based Cell Culture Model to Perform 3D in vitro Cell Signaling Analyses
via labautopedia

Created page with "{{Header:Invited_article|Validation of a Novel Tumoroid-Based Cell Culture Model to Perform 3D ''in vitro'' Cell Signaling Analyses - Comparison of Results Generated with an '..." New page {{Header:Invited_article|Validation of a...
CDC - Blogs - Preventing Chronic Disease Dialogue – Plasma Vitamin D and Biomarkers of Cardiometabolic Disease Risk in A...
via elbiruniblogspotcom.blogspot

full-text ► CDC - Blogs - Preventing Chronic Disease Dialogue – Plasma Vitamin D and Biomarkers of Cardiometabolic Disease Risk in Adult Canadians, 2007–2009 Due to the lapse in government funding, only web sites supporting excepted functions...
Drug Targeting: Protein Study Suggests Drug Side Effects are Inevitable – and that Basic Physics Enabled Early Biochemis...
via gtresearchnews.gatech

A new study of both computer-created and natural proteins suggests that the number of unique pockets – sites where small molecule pharmaceutical compounds can bind to proteins – is surprisingly small, meaning drug side effects may be impossible...
Binimetinib in phase 3 for for the treatment of metastatic or unresectable cutaneous melanoma with NRAS mutations and in...
via newdrugapprovals.wordpress

Binimetinib 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide 5-(4-Bromo-2-fluorophenylamino)-4-fluoro-1-methyl-1H-benzimidazole-6-carbohydroxamic acid 2-hydroxyethyl ester 6-(4...

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Practical Fragments

This blog is meant to allow Fragment-based Drug Design Practitioners to get together and discuss NON-CONFIDENTIAL issues regarding fragments.
Practical Fragments: Covalent fragments writ large

We’ve written previously about irreversible covalent fragment-based lead discovery. The nice thing about irreversible inhibitors is that t...

Practical Fragments: November 2014

12 November 2014 Epigenetics is big. Wicked big. How big? This big. Papers come from everywhere. In this paper, an academic group from Minnesota, goes after SIRT2 with fragments. SIRT2 is a typ...